Resting CD4+ T cells are resistant to HIV-1 infection, but the underlying reasons for this lack of permissiveness have not been clear. Oliver Fackler and colleagues now report that SAMHD1, the deoxynucleoside triphosphate triphosphohydrolase responsible for restriction of HIV-1 infection in myeloid cells, also restricts infection of resting CD4+ T cells. The findings shed new light on the mechanisms of cellular and molecular regulation of HIV-1 infection.
- Hanna-Mari Baldauf
- Xiaoyu Pan
- Oliver T Keppler
