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Showing 1–5 of 5 results
Advanced filters: Author: Ehud Herbst Clear advanced filters

  • In response to phage infection, the Toll/interleukin-1 receptor (TIR) domain protein ThsB of the type II Thoeris defence system produces histidine conjugated to ADP-ribose, which stimulates bacterial defence by interacting with the Macro domain of the ThsA membrane effector protein.

    • Dziugas Sabonis
    • Carmel Avraham
    • Giedre Tamulaitiene
    Research
    Nature
    Volume: 642, P: 467-473

  • We identified Tad1, a large family of phage-encoded proteins that inhibit Thoeris immunity, and define the chemical structure of a central immune signalling molecule, showing a new mode of action by which pathogens can suppress host immunity.

    • Azita Leavitt
    • Erez Yirmiya
    • Rotem Sorek
    Research
    Nature
    Volume: 611, P: 326-331

  • The mechanism of Thoeris—a bacterial anti-phage defence system—is described in detail, revealing that bacterial TIR-domain proteins recognize infection and produce signalling molecules to execute cell death, akin to the roles of these proteins in plants.

    • Gal Ofir
    • Ehud Herbst
    • Rotem Sorek
    Research
    Nature
    Volume: 600, P: 116-120

  • Construction of yeast libraries is time-consuming, costly and limited to the genetic background of the chosen strain. Here the authors present CASTLING which uses CRISPR-Cas12a and oligonucleotide pools to rapidly generate pooled libraries with large insertions such as fluorescent protein tags.

    • Benjamin C. Buchmuller
    • Konrad Herbst
    • Michael Knop
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13