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Showing 1–7 of 7 results
Advanced filters: Author: Eiman Azim Clear advanced filters

  • Improved treatments for spinal-cord injury require both technological development and insights into the biology of recovery. High-resolution molecular maps of the nervous system are beginning to provide the latter.

    • Kee Wui Huang
    • Eiman Azim
    News & Views
    Nature
    Volume: 611, P: 452-453

  • Activity in anterior deep cerebellar nuclei reduces food consumption in mice without reducing metabolic rate, potentially identifying a therapeutic target for disorders involving excessive eating.

    • Aloysius Y. T. Low
    • Nitsan Goldstein
    • J. Nicholas Betley
    Research
    Nature
    Volume: 600, P: 269-273

  • Cervical propriospinal neurons (PNs) form a genetically accessible subclass of V2a interneurons that convey both premotor output and precerebellar copy signals; their ablation in mice impairs reaching movements selectively, and activation of their internal copy projection recruits a rapid cerebellar feedback loop that modulates forelimb movement.

    • Eiman Azim
    • Juan Jiang
    • Thomas M. Jessell
    Research
    Nature
    Volume: 508, P: 357-363

  • Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus offering a potential therapeutic strategy.

    • Noriyuki Kishi
    • Jessica L. MacDonald
    • Jeffrey D. Macklis
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • A population of spinal interneurons that form axo–axonic connections with the terminals of proprioceptive afferents are shown to mediate presynaptic inhibition; their ablation elicits harmonic oscillations during goal-directed forelimb movements, which can be modelled as the consequence of an increase in sensory feedback gain.

    • Andrew J. P. Fink
    • Katherine R. Croce
    • Eiman Azim
    Research
    Nature
    Volume: 509, P: 43-48

  • The closely related Sox5 and Sox6 turn out to perform distinct functions during brain development. Maintenance of the ventricular zone neuroepithelium requires Sox6 in the dorsal and Sox5 in the ventral telencephalon. A portion of the interneurons born in ventral telencephalon then express Sox6, which is necessary for their correct migration and phenotypic differentiation.

    • Eiman Azim
    • Denis Jabaudon
    • Jeffrey D Macklis
    Research
    Nature Neuroscience
    Volume: 12, P: 1238-1247