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Advanced filters: Author: Eirini Vagena Clear advanced filters

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Autoimmune brain inflammation is associated with activation of macrophages and microglia. Here the authors show that fibrinogen induces encephalitogenic T-cell activation and macrophage recruitment to the central nervous system, and promotes demyelination in a mouse model of multiple sclerosis.

Jae Kyu Ryu
Mark A. Petersen
Katerina Akassoglou
ResearchOpen Access10 Sept 2015
Nature Communications

Volume: 6, P: 1-15
Nuclear pore complex remodeling by p75^NTR cleavage controls TGF-β signaling and astrocyte functions

The authors show that changes in nuclear dynamics of p75^NTR by γ-secretase cleavage are a novel molecular switch that determines TGF-β signaling in astrocytes. Cleaved p75^NTR acts as a component of the nuclear pore complex, regulating nuclear import of Smad-2 in astrocytes. The authors find that p75^NTR is required in mice for TGF-β-induced glial scar formation and reduced neuronal activity.

Christian Schachtrup
Jae Kyu Ryu
Katerina Akassoglou
Research29 Jun 2015
Nature Neuroscience

Volume: 18, P: 1077-1080
A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling

Eirini Vagena
Jae Kyu Ryu
George S. Baillie
ResearchOpen Access10 May 2019
Translational Psychiatry

Volume: 9, P: 1-15

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