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Showing 1–4 of 4 results
Advanced filters: Author: Ekaterina Aladyeva Clear advanced filters

  • To gain insights into the early immune dynamics of transcriptional changes during SARS-CoV-2 infection, Singh et al. provide longitudinal scRNA-Seq of the broncho-alveolar compartment of SARS-CoV-2 infected rhesus macaques. They observe an accumulation of a distinct macrophage population that possesses an interferon-driven innate anti-viral gene signature early during infection that correlates with viral clearance.

    • Dhiraj K. Singh
    • Ekaterina Aladyeva
    • Deepak Kaushal
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the type I interferon production.

    • Tomas Paulenda
    • Barbora Echalar
    • Maxim N. Artyomov
    Research
    Nature Metabolism
    Volume: 7, P: 1183-1203

  • A study finds T cells in areas of tau, not amyloid, pathology in Alzheimer’s disease brain and mouse models, with their presence correlating with neuronal loss and their depletion, or that of microglia, preventing neurodegeneration and cognitive decline.

    • Xiaoying Chen
    • Maria Firulyova
    • David M. Holtzman
    Research
    Nature
    Volume: 615, P: 668-677