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Showing 1–5 of 5 results
Advanced filters: Author: Ela Elyada Clear advanced filters

  • Cancer-associated fibroblasts (CAFs) are abundant in the stroma of pancreatic ductal carcinoma (PDAC) tumors. In this study, the authors demonstrate using human samples and mouse models that senescent CAFs impair CD8+ T cell responses and may contribute to poor responsiveness to immunotherapy in PDAC.

    • Benjamin Assouline
    • Rachel Kahn
    • Ittai Ben-Porath
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • This study shows, via a mouse model of intestinal cancer, that in the absence of CKIα, the loss of p53 dramatically enhances tumour progression and metastasis. p53 is shown to normally limit cancer cell invasion via the regulation of p21 and a set of invasion genes that include Prox1. This study adds important insights to the emerging picture that during tumour development the p53 tumour suppressor gene not only controls cell death and proliferation but also metastasis.

    • Ela Elyada
    • Ariel Pribluda
    • Yinon Ben-Neriah
    Research
    Nature
    Volume: 470, P: 409-413

  • In two mouse models of intestinal cancer, mutant p53 has an oncogenic effect in the distal gut but a tumour-suppressive effect in the proximal gut, and these opposing properties are determined by the gut microbiome.

    • Eliran Kadosh
    • Irit Snir-Alkalay
    • Yinon Ben-Neriah
    Research
    Nature
    Volume: 586, P: 133-138