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Showing 1–5 of 5 results
Advanced filters: Author: Eleanna Kaffe Clear advanced filters
  • IL-10 exerts its anti-inflammatory activity in macrophages by increasing the expression of enzymes that promote fatty acid desaturation and downstream regulation of the transcription factor REL.

    • Autumn G. York
    • Mathias H. Skadow
    • Richard A. Flavell
    ResearchOpen Access
    Nature
    Volume: 627, P: 628-635
  • Regulatory T (Treg) cells have an important role in age-related diseases and inflammation; however, the underlying mechanisms are not fully understood. Li et al. identify a Treg-specific long noncoding RNA, Altre, that binds Yin Yang 1 to regulate liver Treg mitochondrial function in old mice. Altre deletion accelerates aging-associated liver pathogenesis.

    • Chenbo Ding
    • Zhibin Yu
    • Hua-Bing Li
    Research
    Nature Aging
    Volume: 3, P: 813-828
  • A mouse model of chronic COVID-19 facilitates the study of disease mechanisms and therapies.

    • Esen Sefik
    • Benjamin Israelow
    • Richard A. Flavell
    Research
    Nature Biotechnology
    Volume: 40, P: 906-920
  • Single-cell RNA-sequencing analysis of intestinal mesenchyme identified a population of fibroblasts that produce prostaglandin E2, which, when disrupted, prevented initiation of intestinal tumours.

    • Manolis Roulis
    • Aimilios Kaklamanos
    • Richard A. Flavell
    Research
    Nature
    Volume: 580, P: 524-529