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Showing 1–3 of 3 results
Advanced filters: Author: Elena Anso Clear advanced filters

  • Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.

    • Elena Ansó
    • Samuel E. Weinberg
    • Navdeep S. Chandel
    Research
    Nature Cell Biology
    Volume: 19, P: 614-625

  • The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes. Here, the authors show that NKX2-3 is a bona fideoncogenic driver in marginal-zone B-cell lymphoma and that it promotes lymphomagenesis by shaping lymphocyte dynamics and promoting BCR signalling.

    • Eloy F. Robles
    • Maria Mena-Varas
    • Jose A. Martinez-Climent
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • Franzoso and colleagues show that NF-κB protects cells from nutrient-starvation-induced necrosis by upregulating mitochondrial respiration through increased p53-dependent expression of the SCO2 enzyme. Conversely, inhibition of NF-κB results in increased aerobic glycolysis, known as the Warburg effect, thus promoting oncogenic transformation, and affects metabolic adaptation during tumorigenesis in vivo.

    • Claudio Mauro
    • Shi Chi Leow
    • Guido Franzoso
    Research
    Nature Cell Biology
    Volume: 13, P: 1272-1279