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Showing 1–7 of 7 results
Advanced filters: Author: Elena K. Stamenova Clear advanced filters

  • Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.

    • Megha Subramanian
    • James McIninch
    • Vasant Jadhav
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • In chronic lymphocytic leukemia (CLL), evolution is driven by transcriptional and epigenetic heterogeneity. Here, the authors integrate epigenomic analyses to show how intra-tumoral epigenetic diversity results in divergent chromatin states in CLL cells, increasing cell-to-cell transcriptional heterogeneity.

    • Alessandro Pastore
    • Federico Gaiti
    • Dan A. Landau
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The phenotypic consequence of 3D genome boundary disruption on developmental processes remains insufficiently understood. Here, the authors show that perturbation of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiation and that germline variations affecting such boundaries are subject to selection, resulting in underrepresentation in the human population.

    • Hua-Jun Wu
    • Alexandro Landshammer
    • Franziska Michor
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Catalytically inactive Cas9 fused to a methyltransferase has emerged as a promising epigenome modifying tool. Here the authors generate a methylation depleted but maintenance competent mouse ES cell line and find ubiquitous off-target activity.

    • Christina Galonska
    • Jocelyn Charlton
    • Alexander Meissner
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Investigation of FOXA2, GATA4 and OCT4 binding across several cell types provides insights into the genetic determinants and epigenetic effects of pioneer-factor occupancy. The data suggest that FOXA2 samples most of its potential binding sites but is stabilized at only a subset of targets.

    • Julie Donaghey
    • Sudhir Thakurela
    • Alexander Meissner
    Research
    Nature Genetics
    Volume: 50, P: 250-258