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Advanced filters: Author: Eleni Kafkia Clear advanced filters

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells

Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferase activity and the pluripotency network.

Karlien Van Nerum
Anne Wenzel
Jan Jakub Żylicz
ResearchOpen Access23 Apr 2025
Nature Cell Biology

Volume: 27, P: 749-761
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community

Using kefir as a natural model microbial ecosystem, the authors apply metabolomics, transcriptomics and large-scale mapping of inter-species interactions to study the drivers of stable coexistence of species in space and time.

Sonja Blasche
Yongkyu Kim
Kiran Raosaheb Patil
Research04 Jan 2021
Nature Microbiology

Volume: 6, P: 196-208
Bioaccumulation of therapeutic drugs by human gut bacteria

An analysis of the interactions between 15 drugs and 25 gut bacterial strains shows that bioaccumulation of drugs within bacterial cells is another mechanism through which gut microorganisms can alter drug availability and efficacy.

Martina Klünemann
Sergej Andrejev
Kiran R. Patil
Research08 Sept 2021
Nature

Volume: 597, P: 533-538