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Showing 1–5 of 5 results
Advanced filters: Author: Eleni Maniati Clear advanced filters

  • Interleukin-17 (IL-17) released in the tumor microenvironment in response to drugs blocking vascular endothelial growth factor (VEGF) triggers stromal-derived inflammatory and VEGF-independent angiogenic programs that induce the drug refractoriness found in cancers resistant to anti-angiogenic therapy (pages 1114–1123).

    • Eleni Maniati
    • Thorsten Hagemann
    News & Views
    Nature Medicine
    Volume: 19, P: 1092-1094

  • Chemotherapy causes changes to immune infiltration and activation in high grade serous ovarian cancer patients. Here, the authors use single cell RNA-seq to identify key markers differentially expressed on macrophages and Treg cell types following treatment which may affect treatment response.

    • Samar Elorbany
    • Chiara Berlato
    • Frances Balkwill
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • The basement membrane stiffness is shown to be a more dominant determinant than pore size in regulating cancer cell invasion, metastasis formation and patient survival. This stiffness is now known to be affected by the ratio of netrin-4 to laminin, with more netrin-4 leading to softer basement membranes.

    • Raphael Reuten
    • Sina Zendehroud
    • Janine T. Erler
    Research
    Nature Materials
    Volume: 20, P: 892-903