Patients with classic Hodgkin lymphoma (cHL) respond well to PD-1 blockade, but the underlying cellular insights are still lacking. Here, the authors use single-cell transcriptome and spatial analyses to identify distinct circulating and tumor-infiltrating CD4+ T cell, B cell and IL1β+ monocyte/macrophage features associated with response to PD-1 blockade in cHL.
- Julia Paczkowska
- Ming Tang
- Margaret A. Shipp
