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Showing 1–4 of 4 results
Advanced filters: Author: Eleonora Zakharian Clear advanced filters

  • Transient receptor potential (TRP) channels are ubiquitous occurring cation-selective sensory ion channels that respond to various stimuli. Here the authors characterize crTRP1 from the alga Chlamydomonas reinhardtii, present its 3.5 Å cryo-EM structure and show that crTRP1 opens in response to increased temperature and is positively regulated by the membrane lipid PIP2.

    • Luke L. McGoldrick
    • Appu K. Singh
    • Alexander I. Sobolevsky
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Cryo-EM structures of mouse TRPV3 in open, closed and intermediate states, obtained by incubation of the protein samples at different temperatures immediately prior to freezing, offer insight into conformational changes induced by heat in TRPV3.

    • Appu K. Singh
    • Luke L. McGoldrick
    • Alexander I. Sobolevsky
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 994-998