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Showing 1–2 of 2 results
Advanced filters: Author: Elianna Amin Clear advanced filters

  • Several studies have recently demonstrated the role of the MSI2 RNA binding protein in normal and malignant haematopoietc stem cells. In this study, the authors show that MSI2 is required for maintaining myelodysplastic syndrome stem cells in mice and that MSI2 expression predicts poor prognosis in patients affected by this disease.

    • James Taggart
    • Tzu-Chieh Ho
    • Michael G. Kharas
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • Michael Kharas and colleagues characterize the MSI2 protein interactome in leukemia cells and subsequently perform a functional screen identifying 24 genes required for leukemia in vivo. They focus on the RNA-binding protein SYNCRIP, showing that it regulates Hoxa9 and other transcripts involved in a myeloid leukemia stem cell program.

    • Ly P Vu
    • Camila Prieto
    • Michael G Kharas
    Research
    Nature Genetics
    Volume: 49, P: 866-875