Nature Search

Human embryo research: how to move towards a 28-day limit

The decades-old limit on how long human embryos can be grown in culture is under debate. A new road map outlines how to extend the length of culture responsibly.

Alejandro De Los Angeles
Nissim Benvenisty
Robin Lovell-Badge
Comments & Opinion01 Jul 2025
Nature

Volume: 643, P: 31-34
Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential

Justin Thomas
Ludovic Zimmerlin
Elias T. Zambidis
ReviewsOpen Access17 May 2021
npj Regenerative Medicine

Volume: 6, P: 1-13
Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment

Viral infection is a common risk for immune-compromised individuals, particularly pediatric patients receiving hematopoietic stem cell transplants. Here the authors report a phase II trial testing adoptive transfer of third party, virus-specific T cells on the feasibility, safety, clinical responses, as well as homeostasis of antiviral immunity in the recipients.

Michael D. Keller
Patrick J. Hanley
Michael A. Pulsipher
ResearchOpen Access18 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina

hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mouse retina than conventional PSCs.

Tea Soon Park
Ludovic Zimmerlin
Elias T. Zambidis
ResearchOpen Access05 Mar 2020
Nature Communications

Volume: 11, P: 1-20
Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

Induced pluripotent stem cells (iPSCs) hold great potential for modelling human developmental processes and diseases. Here the authors induce human iPSCs to spontaneously form fully laminated three-dimensional retinal tissue containing functional photoreceptor cells.

Xiufeng Zhong
Christian Gutierrez
M. Valeria Canto-Soler
Research10 Jun 2014
Nature Communications

Volume: 5, P: 1-14
Why it is important to study human–monkey embryonic chimeras in a dish

The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance and future of human–monkey chimera research within the context of current scientific and regulatory obstacles.

Alejandro De Los Angeles
Alan Regenberg
Elias T. Zambidis
Comments & Opinion25 Jul 2022
Nature Methods

Volume: 19, P: 914-919
Variability of Action Potentials Within and Among Cardiac Cell Clusters Derived from Human Embryonic Stem Cells

Renjun Zhu
Michal A. Millrod
Leslie Tung
ResearchOpen Access05 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
Harnessing bioengineered myeloid progenitors for precision immunotherapies

Willem Buys
Elias T. Zambidis
ReviewsOpen Access12 Dec 2023
npj Regenerative Medicine

Volume: 8, P: 1-9

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