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Showing 1–4 of 4 results
Advanced filters: Author: Elio A. Abbondanzieri Clear advanced filters

  • HIV-1 reverse transcriptase (RT) is an important drug target. RT has two activities, DNA synthesis, and cleavage of a DNA–RNA hybrid. These activities require that RT bind to both DNA and RNA. Single-molecule technology is used to show that the enzyme binds to RNA and DNA in different orientations, and provide insight into how it can flip between these orientations and activities without dissociating from the substrate.

    • Elio A. Abbondanzieri
    • Gregory Bokinsky
    • Xiaowei Zhuang
    Research
    Nature
    Volume: 453, P: 184-189

  • Coordination between subunits is crucial for the proper functioning of multi-component molecular machines. A single-molecule study now allows glimpses into the mechanism used by subunits of one such machine.

    • Elio A. Abbondanzieri
    • Xiaowei Zhuang
    News & Views
    Nature
    Volume: 457, P: 392-393