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Showing 1–2 of 2 results
Advanced filters: Author: Elisa Cappuzzello Clear advanced filters

  • Activation of YAP contributes to tumorigenesis in several tissues. Here, the authors show that in breast cancer cells glucocorticoids induce expression of fibronectin that in turn activates focal adhesion kinase/Src signalling to promote YAP nuclear translocation and transcriptional activity.

    • Giovanni Sorrentino
    • Naomi Ruggeri
    • Giannino Del Sal
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a quinone-mimicking compound that elicits reactive oxygen generation and causes DNA damage.

    • Elena Campaner
    • Alessandra Rustighi
    • Giannino Del Sal
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15