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Showing 1–2 of 2 results
Advanced filters: Author: Elisa Maria Wecht Clear advanced filters

  • Alternative lengthening of telomeres (ALT) is associated with a poor outcome in neuroblastoma. Here, the authors find that ALT is associated with mutated ATRX and/or reduced protein abundance, frequent telomeric repeat loci and heterochromatic telomeric chromatin.

    • Sabine A. Hartlieb
    • Lina Sieverling
    • Frank Westermann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Alborzinia et al. report that MYCN-amplified neuroblastoma undergoes ferroptosis in the absence of intracellular cysteine, suggesting a combination of cysteine depletion and concomitant GPX4 inactivation as a potential therapeutic approach.

    • Hamed Alborzinia
    • Andrés F. Flórez
    • Frank Westermann
    ResearchOpen Access
    Nature Cancer
    Volume: 3, P: 471-485