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Advanced filters: Author: Elisabeth Arlt Clear advanced filters

  • Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the lung.

    • Barbara Spix
    • Elisabeth S. Butz
    • Christian Grimm
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18