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Showing 1–3 of 3 results
Advanced filters: Author: Elisabeth K. Malle Clear advanced filters

  • Insulin replacement is a valuable therapy for insulin deficiency, however, other therapies are being investigated to restore metabolic homeostasis. Here, the authors identify S100A9 as a leptin induced circulating cue that improves glucose and lipid homeostasis and extends survival in insulin deficient mice.

    • Giorgio Ramadori
    • Sanda Ljubicic
    • Roberto Coppari
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • A20, encoded by TNFAIP3, is a negative-feedback inhibitor of NF-κB. Grey and colleagues identify natural human variants of TNFAIP3, which lower A20 activity and increase autoinflammatory responses. These alleles were inherited by descendants of Denisovans who crossed the Wallace Line to inhabit Oceania.

    • Nathan W. Zammit
    • Owen M. Siggs
    • Shane T. Grey
    Research
    Nature Immunology
    Volume: 20, P: 1299-1310