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A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans

Transcription factor Rme1 regulates meiosis and pseudohyphal growth in baker’s yeast, but its role in the meiosis-defective pathogen Candida albicans is unclear. Here, Hernández-Cervantes et al. show that Rme1 activates the expression of genes required for formation of asexual spores in Candida species.

Arturo Hernández-Cervantes
Sadri Znaidi
Christophe d’Enfert
ResearchOpen Access04 Dec 2020
Nature Communications

Volume: 11, P: 1-16
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Genome-wide association analyses of two oral glucose tolerance test-derived measures of postprandial insulin resistance discover ten new loci. Functional characterization identifies nine candidate genes implicated in the regulation of GLUT4.

Alice Williamson
Dougall M. Norris
Claudia Langenberg
Research08 Jun 2023
Nature Genetics

Volume: 55, P: 973-983
Smooth trends in fermium charge radii and the impact of shell effects

Laser spectroscopy measurements of the fermium isotopic chain show a smooth trend in the nuclear size of heavy actinide elements, and diminishing shell effects on the size evolution compared with lighter nuclei.

Jessica Warbinek
Elisabeth Rickert
Klaus Wendt
ResearchOpen Access30 Oct 2024
Nature

Volume: 634, P: 1075-1079
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the lung.

Barbara Spix
Elisabeth S. Butz
Christian Grimm
ResearchOpen Access14 Jan 2022
Nature Communications

Volume: 13, P: 1-18
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

Felix Beuschlein, Martin Reincke and colleagues identify recurrent somatic mutations in ATP1A1 and ATP2B3 in aldosterone-producing adenomas with wild-type KCNJ5. The ATP1A1 and ATP2B3 mutations alter conserved residues and lead to impaired sodium, potassium and calcium ion homeostasis.

Felix Beuschlein
Sheerazed Boulkroun
Martin Reincke
Research17 Feb 2013
Nature Genetics

Volume: 45, P: 440-444
Specific Serotonin Reuptake Inhibition in Major Depressive Disorder Adversely Affects Novel Markers of Cardiac Risk

Tye Dawood
Elisabeth A Lambert
Gavin W Lambert
Research01 Apr 2007
Hypertension Research

Volume: 30, P: 285-293
The neural signature of psychomotor disturbance in depression

Florian Wüthrich
Stephanie Lefebvre
Sebastian Walther
ResearchOpen Access01 Dec 2023
Molecular Psychiatry

Volume: 29, P: 317-326
Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae

Ulrike Grienke
Martina Richter
Judith M. Rollinger
ResearchOpen Access03 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
Sequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility

Zhongli Xu
Susanne von Grafenstein
Michaela Schmidtke
ResearchOpen Access29 Apr 2016
Scientific Reports

Volume: 6, P: 1-12
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease

Andrew A. Crawford
Sean Bankier
Dan Mellström
ResearchOpen Access20 Jan 2021
Journal of Human Genetics

Volume: 66, P: 625-636

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A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Smooth trends in fermium charge radii and the impact of shell effects

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

Specific Serotonin Reuptake Inhibition in Major Depressive Disorder Adversely Affects Novel Markers of Cardiac Risk

The neural signature of psychomotor disturbance in depression

Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae

Sequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease

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