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Showing 1–3 of 3 results
Advanced filters: Author: Elisabetta Traggiai Clear advanced filters

  • Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.

    • Louis Pérol
    • John M. Lindner
    • Eliane Piaggio
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • New immunotherapies have the potential to mediate a sustained remission from certain autoimmune diseases. This has been referred to as achieving an ‘immune reset’ in patients. Here, Junt and colleagues discuss how we can most accurately define the term immune reset and explain the challenges in identifying suitable biomarkers of long-term disease remission.

    • Tobias Junt
    • Thomas Calzascia
    • Richard M. Siegel
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 528-541