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Showing 1–3 of 3 results
Advanced filters: Author: Elise Alspach Clear advanced filters

  • Obesity represents a risk factor for cancer and compromises immune function, however the mechanisms linking the two together are not fully known. Here authors show in a mouse sarcoma model that obesity increases tumour incidence, impairs intra-tumoral T cell immunity but paradoxically increases sensitivity to immune therapy via impairing immunoediting.

    • Alexander Piening
    • Emily Ebert
    • Ryan M. Teague
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • In a mouse tumour model, immunotherapy-induced rejection of tumour cells requires presentation of both MHC class I and MHC class II antigens, which activate CD4+ and CD8+ T cells, respectively.

    • Elise Alspach
    • Danielle M. Lussier
    • Robert D. Schreiber
    Research
    Nature
    Volume: 574, P: 696-701

  • The risk of developing cancer increases with age. Here, the authors address the contribution of age-dependent accumulation of senescent cells within the tumour stroma compartment and show that senescent cells increase the infiltration of myeloid-derived suppressor cells that inhibit cytotoxic T-cells, thus facilitating tumour outgrowth.

    • Megan K. Ruhland
    • Andrew J. Loza
    • Sheila A. Stewart
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-18