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Showing 1–4 of 4 results
Advanced filters: Author: Elise Fouquerel Clear advanced filters

  • DNA damage caused by ultraviolet irradiation is removed from the genome by nucleotide excision repair; however, it is unclear if this occurs at chromosome ends. Here the authors provide evidence indicating that telomeres are partially shielded from damage and that repair is fully functional.

    • Dhvani Parikh
    • Elise Fouquerel
    • Patricia L. Opresko
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • A combination of biochemical, single-molecule, and in vivo assays reveals that the UV-DDB complex that removes UV-induced DNA lesions via the nucleotide excision repair pathway also promotes removal of oxidative lesions via base excision repair.

    • Sunbok Jang
    • Namrata Kumar
    • Bennett Van Houten
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 695-703

  • Opposing effects of 8-oxodGTP on telomerase activity – promoting elongation by destabilizing G4 structures or inhibiting elongation by acting as a chain terminator – explain the differential sensitivity of cells with short telomeres to oxidative stress.

    • Elise Fouquerel
    • Justin Lormand
    • Patricia L Opresko
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 1092-1100