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Showing 1–2 of 2 results
Advanced filters: Author: Eliza Joodmardi Clear advanced filters

  • Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad mDA neuronal marker) to identify and characterize seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons.

    • Katarína Tiklová
    • Åsa K. Björklund
    • Thomas Perlmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • This study establishes a key role for the developmental transcription factors Lmx1a/b in the maintenance of midbrain dopamine neurons. The authors show that postmitotic ablation of Lmx1b in mice leads to cellular and functional abnormalities resembling Parkinson's disease, most notably in a dysfunction in the autophagic-lysosomal pathway that results in abnormal dopaminergic synaptic connections and neuronal degeneration.

    • Ariadna Laguna
    • Nicoletta Schintu
    • Thomas Perlmann
    Research
    Nature Neuroscience
    Volume: 18, P: 826-835