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Showing 1–5 of 5 results
Advanced filters: Author: Elizabeth A. Pollina Clear advanced filters

  • A neuron-specific activity-dependent DNA repair mechanism is identified, the impairment of which may lead to neurodevelopmental disorders, neurodegeneration and ageing.

    • Elizabeth A. Pollina
    • Daniel T. Gilliam
    • Michael E. Greenberg
    ResearchOpen Access
    Nature
    Volume: 614, P: 732-741

  • The chromatin-based epigenetic changes that occur during ageing and the role of chromatin modifiers in lifespan have recently been highlighted. The importance of epigenome remodelling by environmental stimuli for transcriptional and genomic stability is emerging, and such remodelling could provide new targets to counter ageing or age-related diseases.

    • Bérénice A. Benayoun
    • Elizabeth A. Pollina
    • Anne Brunet
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 593-610

  • Oligodendrocytes produce myelin in the central nervous system and can regenerate in adults. Brunet and colleagues show that inactivation of SIRT1 deacetylase increases the proliferation of oligodendrocyte progenitors partly by shifting other neural stem cells to this fate. Using genome-wide approaches, they delineate PDGFRα as a critical target of SIRT1 in its negative effects on oligodendrocyte lineage.

    • Victoria A. Rafalski
    • Peggy P. Ho
    • Anne Brunet
    Research
    Nature Cell Biology
    Volume: 15, P: 614-624

  • Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

    • Meng How Tan
    • Qin Li
    • Jin Billy Li
    Research
    Nature
    Volume: 550, P: 249-254