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Expanded CD16⁺CD56⁺Granzyme B⁺ NK like CD8⁺ T cells an off target effect of bruton’s tyrosine kinase inhibitors in Waldenström macroglobulinemia

Priyanka Hastak
Chansavath Phetsouphanh
Sarah C. Sasson
ResearchOpen Access05 Oct 2025
Scientific Reports

Volume: 15, P: 1-13
When suffragists kicked open the lab door

Elizabeth Bruton lauds a book tracing how women in wartime science blazed a path to the vote and beyond.

Elizabeth Bruton
Books & Arts10 Jan 2018
Nature

Volume: 553, P: 154
Human leukocyte interferon produced by E. coli is biologically active

David V. Goeddel
Elizabeth Yelverton
Sidney Pestka
Research02 Oct 1980
Nature

Volume: 287, P: 411-416
Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia

The impact of tumor intrinsic and immune alterations on disease progression in patients with Waldenstrom’s Macroglobulinemia (WM) remains to be characterized. Here, the authors perform single-cell RNA-sequencing and identify distinct tumor subtypes, tumour microenvironment features and potential therapeutic vulnerabilities in patients with WM.

Romanos Sklavenitis-Pistofidis
Yoshinobu Konishi
Irene M. Ghobrial
ResearchOpen Access10 Feb 2025
Nature Communications

Volume: 16, P: 1-19
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

SARS-CoV-2 infection is milder in children, but direct comparison with adults is rare. Here the authors show that immune responses are higher in children, retained for 12 months or longer and can neutralize Alpha, Beta and Delta variants.

Alexander C. Dowell
Megan S. Butler
Shamez Ladhani
ResearchOpen Access22 Dec 2021
Nature Immunology

Volume: 23, P: 40-49
Antibody responses after first and second Covid-19 vaccination in patients with chronic lymphocytic leukaemia

H. Parry
G. McIlroy
P. Moss
ResearchOpen Access30 Jul 2021
Blood Cancer Journal

Volume: 11, P: 1-8
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

This study highlights a unique drug target for trypanosomatid parasitic protozoa and a new chemical tool for investigating the function of their divergent kinetochores.

Manuel Saldivia
Eric Fang
Srinivasa P. S. Rao
Research13 Jul 2020
Nature Microbiology

Volume: 5, P: 1207-1216
Recon3D enables a three-dimensional view of gene variation in human metabolism

Large-scale integration of metabolite and protein structural data with existing networks of human metabolism provides insights into gene function and how drugs affect metabolic response.

Elizabeth Brunk
Swagatika Sahoo
Bernhard O Palsson
Research19 Feb 2018
Nature Biotechnology

Volume: 36, P: 272-281
Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

Gina M. Doody
Sarah E. Bell
Martin Turner
Research01 Jun 2001
Nature Immunology

Volume: 2, P: 542-547
Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection

This study shows that during the first wave of SARS-CoV-2 infection in England, residents of long-term care facilities who survived infection developed a robust and stable immunity against the virus that did not negatively impact responses to other seasonal viruses.

Gokhan Tut
Tara Lancaster
Paul Moss
ResearchOpen Access30 May 2022
Nature Aging

Volume: 2, P: 536-547
Metabolic and Genetic Studies of a Family with Ornithine Transcarbamylase Deficiency

Arnold S Goldstein
Nicholas J Hoogenraad
Philip Sunshine
Research01 Jan 1974
Pediatric Research

Volume: 8, P: 5-12
Negative regulation of Toll-like receptor-mediated immune responses

Foo Y. Liew
Damo Xu
Luke A. J. O'Neill
Reviews01 Jun 2005
Nature Reviews Immunology

Volume: 5, P: 446-458
Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins

Yijing Li
Heng-Huan Lee
Yang Liu
ResearchOpen Access02 Nov 2023
Cell Death & Disease

Volume: 14, P: 1-11
VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia

Steven Sher
Ethan Whipp
Rosa Lapalombella
ResearchOpen Access14 Nov 2022
Leukemia

Volume: 37, P: 326-338
Dual inhibition of PI3K signaling and histone deacetylation halts proliferation and induces lethality in mantle cell lymphoma

Hui Guo
Dongfeng Zeng
Michael Wang
Research25 Oct 2018
Oncogene

Volume: 38, P: 1802-1814
Helplessness, self blame and faith may impact on self management in COPD: a qualitative study

Nicolette Sheridan
Timothy Kenealy
Jacqueline Schmidt-Busby
Research21 Apr 2011
Primary Care Respiratory Journal

Volume: 20, P: 307-314
Increased sensitivity to cis-diamminedichloroplatinum induced apoptosis with mitochondrial DNA depletion

Bertrand C Liang
Elizabeth Ullyatt
Research03 Aug 1998
Cell Death & Differentiation

Volume: 5, P: 694-701
Extraordinary clinical response to ibrutinib in low-grade ovarian cancer guided by organoid drug testing

Heidi J. Gray
Payel Chatterjee
Carla Grandori
ResearchOpen Access18 May 2023
npj Precision Oncology

Volume: 7, P: 1-6
Long-term follow-up of ibrutinib monotherapy in treatment-naive patients with Waldenstrom macroglobulinemia

Jorge J. Castillo
Kirsten Meid
Steven P. Treon
ResearchOpen Access16 Sept 2021
Leukemia

Volume: 36, P: 532-539
Ibrutinib for bridging to allogeneic hematopoietic cell transplantation in patients with chronic lymphocytic leukemia or mantle cell lymphoma: a study by the EBMT Chronic Malignancies and Lymphoma Working Parties

Peter Dreger
Mauricette Michallet
Johannes Schetelig
Research04 May 2018
Bone Marrow Transplantation

Volume: 54, P: 44-52
Ibrutinib reprograms the glucocorticoid receptor in chronic lymphocytic leukemia cells

Yonghong Shi
Guizhi Wang
David E. Spaner
Research29 Jan 2019
Leukemia

Volume: 33, P: 1650-1662
Mixed methods process evaluation of my breathing matters, a digital intervention to support self-management of asthma

Kate Greenwell
Ben Ainsworth
Lucy Yardley
ResearchOpen Access04 Jun 2021
npj Primary Care Respiratory Medicine

Volume: 31, P: 1-13
If we build it they will come: targeting the immune response to breast cancer

Margaret E. Gatti-Mays
Justin M. Balko
Elizabeth A. Mittendorf
ReviewsOpen Access29 Oct 2019
npj Breast Cancer

Volume: 5, P: 1-13
HIT-COVID, a global database tracking public health interventions to COVID-19

Qulu Zheng
Forrest K. Jones
Navdeep Singh
ResearchOpen Access27 Aug 2020
Scientific Data

Volume: 7, P: 1-8

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Expanded CD16⁺CD56⁺Granzyme B⁺ NK like CD8⁺ T cells an off target effect of bruton’s tyrosine kinase inhibitors in Waldenström macroglobulinemia

When suffragists kicked open the lab door

Human leukocyte interferon produced by E. coli is biologically active

Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia

Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Antibody responses after first and second Covid-19 vaccination in patients with chronic lymphocytic leukaemia

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

Recon3D enables a three-dimensional view of gene variation in human metabolism

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection

Metabolic and Genetic Studies of a Family with Ornithine Transcarbamylase Deficiency

Negative regulation of Toll-like receptor-mediated immune responses

Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins

VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia

Dual inhibition of PI3K signaling and histone deacetylation halts proliferation and induces lethality in mantle cell lymphoma

Helplessness, self blame and faith may impact on self management in COPD: a qualitative study

Increased sensitivity to cis-diamminedichloroplatinum induced apoptosis with mitochondrial DNA depletion

Extraordinary clinical response to ibrutinib in low-grade ovarian cancer guided by organoid drug testing

Long-term follow-up of ibrutinib monotherapy in treatment-naive patients with Waldenstrom macroglobulinemia

Ibrutinib for bridging to allogeneic hematopoietic cell transplantation in patients with chronic lymphocytic leukemia or mantle cell lymphoma: a study by the EBMT Chronic Malignancies and Lymphoma Working Parties

Ibrutinib reprograms the glucocorticoid receptor in chronic lymphocytic leukemia cells

Mixed methods process evaluation of my breathing matters, a digital intervention to support self-management of asthma

If we build it they will come: targeting the immune response to breast cancer

HIT-COVID, a global database tracking public health interventions to COVID-19

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