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Showing 1–2 of 2 results
Advanced filters: Author: Elizabeth Connick Clear advanced filters

  • Antibody responses are impaired during HIV and SIV infection. Here the authors show that viral infection contributes to this process by multiple mechanisms acting on regulatory T follicular cells, including their expansion and increased suppression of the follicular T helper cells.

    • Brodie Miles
    • Shannon M. Miller
    • Elizabeth Connick
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-16

  • B cell responses are impaired in HIV-infected individuals. Elias Haddad and colleagues now report that follicular helper T (TFH) cells, which are crucial for the maturation of B cell memory and development of high-affinity antibodies, are functionally impaired upon interaction with lymph node germinal center B cells from HIV-infected individuals. The interaction of the inhibitory molecule PD-1 on TFH cells with its ligand PD-L1, which is elevated on germinal center B cells in HIV-infected lymph nodes, impairs TFH cell proliferation and antibody production by B cells, thus providing insight into humoral dysfunction in HIV infection.

    • Rafael A Cubas
    • Joseph C Mudd
    • Elias K Haddad
    Research
    Nature Medicine
    Volume: 19, P: 494-499