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Showing 1–3 of 3 results

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The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsiveness

Induced regulatory T cells help maintain peripheral tolerance. Flavell and colleagues show that the transcription cofactor Hopx is essential in maintaining the anergy and function of these cells.

Daniel Hawiger
Yisong Y Wan
Richard A Flavell
Research29 Aug 2010
Nature Immunology

Volume: 11, P: 962-968
Intracellular debugging

A family of intracellular molecules called NODs has been proposed to sense bacteria within the cell. New data now show that NOD1 senses a distinct bacterial component and may thus be important in responding to bacteria with this molecular signature.

Koichi S Kobayashi
Elizabeth E Eynon
Richard A Flavell
News & Views01 Jul 2003
Nature Immunology

Volume: 4, P: 652-654
Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice

In a new mouse model of multiple myeloma, mice expressing the human versions of six proteins important for hematopoietic function were able to support the growth of primary human multiple myeloma xenografts, including both preneoplastic and malignant plasma cells.

Rituparna Das
Till Strowig
Madhav V Dhodapkar
Research10 Oct 2016
Nature Medicine

Volume: 22, P: 1351-1357