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Showing 1–7 of 7 results
Advanced filters: Author: Ellinor Johnsson Clear advanced filters

  • Multiple myeloma is an incurable and fatal disease characterized by uninhibited growth of plasma cells in the bone marrow. Here, Swaminathan et al. conduct a genome-wide association study and identify a novel risk locus at ELL2, which encodes a key component of the super-elongation complex.

    • Bhairavi Swaminathan
    • Guðmar Thorleifsson
    • Björn Nilsson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Previous genome-wide association studies have identified loci associated with the risk of multiple myeloma. Here, the authors present a meta-analysis of six genome wide association studies of the disease and identify eight new loci; functional studies identify genes as candidates for the basis of these associations.

    • Jonathan S. Mitchell
    • Ni Li
    • Richard S. Houlston
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility.

    • Molly Went
    • Amit Sud
    • Stephen N. Thibodeau
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • ELL2 was recently discovered as a susceptibility gene for multiple myeloma (MM). Here, they show that the MM risk allele lowers ELL2 expression in plasma cells, that it also upregulates gene sets related to ribosome biogenesis, and that one of the linked variants reduces binding of MAFF/G/K family transcription factors.

    • Mina Ali
    • Ram Ajore
    • Björn Nilsson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Ingileif Jonsdottir, Björn Nilsson, Kari Stefansson and colleagues perform a genome-wide association study for immunoglobulin levels in Icelandic and Swedish cohorts. They find 38 new variants associated with IgA, IgG, IgM or composite immunoglobulin traits and identify candidate genes underlying the regulation of immunoglobulin levels.

    • Stefan Jonsson
    • Gardar Sveinbjornsson
    • Kari Stefansson
    Research
    Nature Genetics
    Volume: 49, P: 1182-1191

  • Maroulio Pertesi, Ludvig Ekdahl et al. identify genes that limit homozygous deletions in cancer cells. This study provides insight into how the location of essential genes affects deletion events, which can be used to identify potentially targetable vulnerabilities in cancer.

    • Maroulio Pertesi
    • Ludvig Ekdahl
    • Björn Nilsson
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-11