Bisphosphonate-associated osteonecrosis (BON) is a rare complication that almost exclusively affects the jaws. BON has only been recognized within the past 10 years; therefore, management strategies for patients with BON are poorly defined. In this Review the authors discuss the pathobiology, diagnosis, presentation, incidence and prevalence of BON, as well as highlighting risk factors and tumor types associated with this complication.
- Cesar A. Migliorati
- Joel B. Epstein
- James R. Berenson
