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Showing 1–4 of 4 results
Advanced filters: Author: Elliot Gerrard Clear advanced filters

    • G. ELLIOT SMITH
    Books & Arts
    Nature
    Volume: 105, P: 605-607

  • Cryo-EM structure and dynamics analysis provides a conformational mechanism for tuning of selectivity between calcitonin and amylin receptors through targeted lipid modification of residues 19–22 within the ‘bypass’ motif of amylin peptides.

    • Jianjun Cao
    • Matthew J. Belousoff
    • Patrick M. Sexton
    Research
    Nature Chemical Biology
    Volume: 20, P: 162-169

  • G-protein coupled receptors (GPCRs) represent the largest receptor family and are prime drug targets, but many orphan GPCRs are poorly characterized. Here authors engineer human orphan GPCRs to be activated by light which allows studying the receptors ligand identity and downstream signaling.

    • Maurizio Morri
    • Inmaculada Sanchez-Romero
    • Harald Janovjak
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10