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Showing 1–7 of 7 results
Advanced filters: Author: Elliot L. Chaikof Clear advanced filters

  • An elastic polymer has been made whose molecular structure mimics that of titin, a protein found in muscle. The resulting material is tough, stretchy and dissipates energy — just like muscle itself.

    • Elliot L. Chaikof
    News & Views
    Nature
    Volume: 465, P: 44-45

  • This Perspective discusses how the Somatic Cell Genome Editing Consortium aims to accelerate the implementation of safe and effective genome-editing therapies in the clinic.

    • Krishanu Saha
    • Erik J. Sontheimer
    • Jiangbing Zhou
    ReviewsOpen Access
    Nature
    Volume: 592, P: 195-204

  • Inhibiting the interaction between the membrane protein P-selectin and its ligand PSGL-1 is thought to block inflammation. Here the authors report an efficient stereoselective synthesis for PSGL-1 glycopeptide mimics and show that these compounds inhibit PSGL-1/P-selectin in vitro and in vivo.

    • Venkata R. Krishnamurthy
    • Mohammed Y. R. Sardar
    • Elliot L. Chaikof
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • Bioactive coatings offer a strategy to modulate host response to implants, but their translation to the clinic is hampered by their fast in vivo degradation. Here, the authors use an engineered bacterial protein to regenerate an anti-thrombogenic film in vitro and in situafter device implantation.

    • Hyun Ok Ham
    • Zheng Qu
    • Elliot L. Chaikof
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8