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Showing 1–12 of 12 results
Advanced filters: Author: Elliott J. Hagedorn Clear advanced filters

  • The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly discovered loci influencing glycemic traits are also associated with risk of type 2 diabetes.

    • Josée Dupuis
    • Claudia Langenberg
    • Inês Barroso
    Research
    Nature Genetics
    Volume: 42, P: 105-116

  • Mark McCarthy and colleagues identify twelve new risk loci for type 2 diabetes through a large-scale genome-wide association and replication study in individuals of European ancestry. The identified loci affect both beta-cell function and insulin action and are enriched for genes involved in cell cycle regulation.

    • Benjamin F Voight
    • Laura J Scott
    • Mark I McCarthy
    Research
    Nature Genetics
    Volume: 42, P: 579-589

  • Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, several of which show stronger effects in women than in men.

    • Iris M Heid
    • Anne U Jackson
    • Cecilia M Lindgren
    Research
    Nature Genetics
    Volume: 42, P: 949-960

  • Tissue remodelling events create gaps in the basement membrane and have been previously accounted for by the degradation or reduced synthesis of basement membrane components. Live-cell imaging shows that basement membrane sliding enlarges the opening of the uterus during Caenorhabditis elegans development and that integrins-based adhesion negatively regulates sliding.

    • Shinji Ihara
    • Elliott J. Hagedorn
    • David R. Sherwood
    Research
    Nature Cell Biology
    Volume: 13, P: 641-651

  • The effect of sequence variants on phenotypes may depend on parental origin. Here, a method is developed that takes parental origin — the impact of which, to date, has largely been ignored — into account in genome-wide association studies. For 38,167 Icelanders genotyped, the parental origin of most alleles is determined; furthermore, a number of variants are found that show associations specific to parental origin, including three with type 2 diabetes.

    • Augustine Kong
    • Valgerdur Steinthorsdottir
    • Kari Stefansson
    Research
    Nature
    Volume: 462, P: 868-874

  • Nathan Pankratz, Santhi Ganesh and colleagues use exome chip data to identify rare and common variants influencing blood cell traits. They report associations at several loci, including a rare missense variant in S1PR4 associated with circulating neutrophil counts, and present functional studies supporting a role for S1PR4 in neutrophil recruitment and resolution in response to tissue injury.

    • Nathan Pankratz
    • Ursula M Schick
    • Santhi K Ganesh
    Research
    Nature Genetics
    Volume: 48, P: 867-876

  • The C.elegans anchor cell is a model for cellular invasion through the basement membrane. Now netrin (UNC-6) is found to polarize the actin regulators Ena/VASP and PtdIns (4,5)P2 towards the basement membrane to promote anchor cell invasion.

    • Joshua W. Ziel
    • Elliott J. Hagedorn
    • David R. Sherwood
    Research
    Nature Cell Biology
    Volume: 11, P: 183-189

  • Using whole-genome data for single-nucleotide polymorphism and results from genome-wide association studies, the authors show that people’s preference for pairing with those with similar phenotypic traits has genetic causes and consequences.

    • Matthew R. Robinson
    • Aaron Kleinman
    • Peter M. Visscher
    Research
    Nature Human Behaviour
    Volume: 1, P: 1-13