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Showing 1–5 of 5 results
Advanced filters: Author: Elmer Guzman Clear advanced filters

  • Low-density lipoprotein receptor-related protein 1 (LRP1) is shown to be a critical determinant of tau propagation in the brain.

    • Jennifer N. Rauch
    • Gabriel Luna
    • Kenneth S. Kosik
    Research
    Nature
    Volume: 580, P: 381-385

  • Brain organoids replicate cellular organization found in the developing human brain. Here, the authors utilize microelectronics to map activity in brain organoids and assemble functional circuits that mirror complexity found in brain networks in vivo.

    • Tal Sharf
    • Tjitse van der Molen
    • Kenneth S. Kosik
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • Kodama et al. show that microglia from male and female adult mice have distinct microRNA profiles and that loss of microglial microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology.

    • Lay Kodama
    • Elmer Guzman
    • Li Gan
    Research
    Nature Neuroscience
    Volume: 23, P: 167-171

  • Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology of mental disorders; this approach was used with samples from a family with a schizophrenia pedigree and a DISC1 mutation, revealing synaptic abnormalities and large-scale transcriptional dysregulation.

    • Zhexing Wen
    • Ha Nam Nguyen
    • Guo-li Ming
    Research
    Nature
    Volume: 515, P: 414-418