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Showing 1–10 of 10 results
Advanced filters: Author: Elphège P. Nora Clear advanced filters

  • The boundaries of topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. Here the authors find that CTCF positions cohesin through its N-terminus but does not control its overall binding dynamics on chromatin, and show how the orientation of CTCF binding sites translates into genome folding patterns.

    • Elphège P. Nora
    • Laura Caccianini
    • Benoit G. Bruneau
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Live-cell imaging shows that interactions within topologically associating domains are transient and frequent throughout the cell cycle. Convergent CTCF sites regulate the frequency and duration of interactions, which last a few minutes on average.

    • Pia Mach
    • Pavel I. Kos
    • Luca Giorgetti
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1907-1918

  • Recent studies have greatly increased our understanding of the molecular actors that regulate X-chromosome inactivation in female mammals. A complex interplay ofcis- and trans-regulatory mechanisms ensures the differential activities of the two X chromosomes during female development.

    • Sandrine Augui
    • Elphège P. Nora
    • Edith Heard
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 429-442

  • Super-resolution microscopy identifies sub-topologically associating domain (TAD) nanodomains and intercellular heterogeneity in TAD conformation and insulation. Cohesin or CTCF depletion regulates distinct types of chromatin contacts at the TAD but not nanodomain level.

    • Quentin Szabo
    • Axelle Donjon
    • Giacomo Cavalli
    Research
    Nature Genetics
    Volume: 52, P: 1151-1157

  • How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.

    • Erika C. Anderson
    • Elphège P. Nora
    News & Views
    Nature Genetics
    Volume: 52, P: 1003-1004

  • CTCF is a conserved DNA- and RNA-binding protein with roles in genome folding and transcriptional regulation. Two recent studies investigated how CTCF knockout perturbs genome biology and derails embryogenesis in zebrafish and Drosophila melanogaster, revealing contrasting effects across species.

    • Geoffrey Fudenberg
    • Elphège P. Nora
    News & Views
    Nature Structural & Molecular Biology
    Volume: 28, P: 774-776

  • Inducible protein degradation technologies enable the depletion of loop extrusion factors within short time frames, leading to the rapid reconfiguration of the 3D genome. Nora and de Wit review insights from degron approaches into the molecular factors controlling genome folding and how these findings have changed our understanding of genome organization, including its role in transcription.

    • Elzo de Wit
    • Elphège P. Nora
    Reviews
    Nature Reviews Genetics
    Volume: 24, P: 73-85

  • Using 4C technology, higher-order topological features of the pluripotent genome are identified; in pluripotent stem cells, Nanog clusters specifically with other pluripotency genes and this clustering is centred around Nanog-binding sites, suggesting that Nanog helps to shape the three-dimensional structure of the pluripotent genome and thereby contributes to the robustness of the pluripotent state.

    • Elzo de Wit
    • Britta A. M. Bouwman
    • Wouter de Laat
    Research
    Nature
    Volume: 501, P: 227-231