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Showing 1–6 of 6 results
Advanced filters: Author: Elsa A Marquez Clear advanced filters

  • RMC-7977, a compound that exhibits potent inhibition of the active states of mutant and wild-type KRAS, NRAS and HRAS variants has a strong anti-tumour effect on RAS-addicted tumours and is well tolerated in preclinical models.

    • Matthew Holderfield
    • Bianca J. Lee
    • Mallika Singh
    ResearchOpen Access
    Nature
    Volume: 629, P: 919-926

  • Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

    • Andrey Ziyatdinov
    • Jason Torres
    • Roberto Tapia-Conyer
    ResearchOpen Access
    Nature
    Volume: 622, P: 784-793

  • Human Langerhans cells express CD1a, but those in mice do not, which makes determination of its function on these cells challenging in vivo. Through the use of a transgenic mouse that expresses CD1a, Winau and colleagues demonstrate that Langerhans cells use CD1a to present contact allergens and self lipid antigens and thereby worsen inflammatory skin conditions.

    • Ji Hyung Kim
    • Yu Hu
    • Florian Winau
    Research
    Nature Immunology
    Volume: 17, P: 1159-1166