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Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

A chemoproteomics approach utilizing the thermal shift assay and quantitative MS resulted in the identification of phenylalanine hydroxylase as an off-target of the histone deacetylase inhibitor panobinostat.

Isabelle Becher
Thilo Werner
Mikhail M Savitski
Research26 Sept 2016
Nature Chemical Biology

Volume: 12, P: 908-910

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Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

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