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Showing 1–3 of 3 results
Advanced filters: Author: Elsa Zacco Clear advanced filters

  • Here, the authors generated an artificial RNA molecule, or aptamer, specific for the Amyotrophic Lateral Sclerosis protein TDP-43. By interacting avidly with its target, the aptamer can be exploited to track TDP-43 phase transition in vitro and in cells.

    • Elsa Zacco
    • Owen Kantelberg
    • Gian Gaetano Tartaglia
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • The wide variety of cellular processes involving biomolecular condensation makes their quantification a challenging task. Here, the authors present an integrated platform based on single-photon microscopy to study complex biomolecular processes.

    • Eleonora Perego
    • Sabrina Zappone
    • Giuseppe Vicidomini
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Paul et al. provide a rational design strategy to develop dual inhibitors, in the form of tryptophan-galactosylamine conjugates, against amyloid formation and aggregation of Aβ42 and hIAPP peptides. These conjugates are not toxic to mammalian cells and reduce cytotoxicity of Aβ42 and hIAPP aggregates, hence potentially could serve as scaffolds for development of Alzheimer’s disease therapeutics.

    • Ashim Paul
    • Moran Frenkel-Pinter
    • Daniel Segal
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-12