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Showing 1–6 of 6 results
Advanced filters: Author: Elton Zeqiraj Clear advanced filters

  • The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactivate BRISC, promoting interferon receptor ubiquitylation and degradation to dampen immune responses.

    • Francesca Chandler
    • Poli Adi Narayana Reddy
    • Elton Zeqiraj
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1812-1824

  • Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synthesis, and delayed radial glial cell specification.

    • Chunyang Ni
    • Yudong Wei
    • Michael Buszczak
    ResearchOpen Access
    Nature Cell Biology
    Volume: 27, P: 1240-1255

  • Cryo-electron microscopy and mutation experiments demonstrate that the inactive SHMT2 dimer—and not the pyridoxal-5′-phosphate-bound tetramer—binds to BRISC, which reveals a mechanism for the regulation of deubiquitylases and inflammatory signalling.

    • Miriam Walden
    • Lei Tian
    • Elton Zeqiraj
    Research
    Nature
    Volume: 570, P: 194-199

  • Glycogen is a major energy reserve in eukaryotes and is synthesised in part by glycogenin (GN) and glycogen synthase (GS). Here, authors describe the structural basis of GS regulation, specifically the mechanism of inactivation by phosphorylation.

    • Laura Marr
    • Dipsikha Biswas
    • Elton Zeqiraj
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14