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Showing 1–4 of 4 results
Advanced filters: Author: Elyssa B. Margolis Clear advanced filters

  • Opioids are potent analgesics but also have addiction risk. Here a lateral preoptic area to lateral habenula connection is identified by which opioids relieve ongoing pain but do not produce reward in animals that do not have ongoing pain.

    • Maggie W. Waung
    • Kayla A. Maanum
    • Elyssa B. Margolis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • δ-Opioid receptors (δOR) are promising targets for pain management with reduced side effects. Here, the authors use a structure-based approach to design and characterize C6-Quino, a selective δOR partial agonist, highlighting its potential therapeutic relevance.

    • Balazs R. Varga
    • Sarah M. Bernhard
    • Tao Che
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Neurons in the ventral tegmental area (VTA) are highly heterogeneous and project to a range of different brain regions. Morales and Margolis summarize recent efforts to characterise VTA neurons, dissect their circuitry and understand their roles in motivation- and reward-related behaviours.

    • Marisela Morales
    • Elyssa B. Margolis
    Reviews
    Nature Reviews Neuroscience
    Volume: 18, P: 73-85