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Showing 1–11 of 11 results
Advanced filters: Author: Emad Moeendarbary Clear advanced filters

  • Glial scars are thought to provide a biochemical and mechanical barrier to neuronal regeneration post-injury, but the mechanical properties of the scars have not been studied in detail. Here the authors perform atomic force microscopy measurements of glial scars from the injured rat cortex and spinal cord, and find that brain tissue softens in response to the injury.

    • Emad Moeendarbary
    • Isabell P. Weber
    • Kristian Franze
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • The mechanobiology of blood brain barrier (BBB) remains underexplored. In this perspective, the authors highlight the emerging importance of mechanical forces in shaping BBB function across development, disease, and ageing. They also argue that integrating biomechanics into BBB research is important for advancing future therapies.

    • Simon Konig
    • Vignesh Jayarajan
    • Emad Moeendarbary
    ReviewsOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The field of biogerontology has established itself through significant lines of research in recent decades. However, despite early breakthroughs, progress in understanding the aging process has been slow. To push the field forward, new methodologies and technologies are likely needed to unravel the complexity of aging. This meeting brought together leading scientists and innovators to explore some emerging approaches, presenting groundbreaking advancements in four key sessions, culminating in a panel discussion.

    • Maximilian Unfried
    • Tomas Schmauck-Medina
    • Morten Scheibye-Knudsen
    News & ViewsOpen Access
    npj Aging
    Volume: 11, P: 1-4

  • Cracks in stretched epithelial tissue are caused by a build-up of hydraulic pressure beneath the cells when the tissue is unloaded.

    • Emad Moeendarbary
    • Guillaume Charras
    News & Views
    Nature Materials
    Volume: 14, P: 268-269

  • Quantifying rapidly progressing three-dimensional forces generated by cells remains a major challenge in mechanobiology. Here, the authors show that combining traction force microscopy with astigmatic imaging permits sensitive out-of-plane force estimation on the second timescale.

    • Di Li
    • Huw Colin-York
    • Marco Fritzsche
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Gap formation in the vasculature underpins immune and tumour cell infiltration. Here the authors propose a chemo-mechanical model to analyse how feedback between mechanosensitive signalling, active cellular forces and adhesion governs the breakdown, recovery, and integrity of endothelial junctions.

    • Eoin McEvoy
    • Tal Sneh
    • Vivek B. Shenoy
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • It is unclear how specific signalling pathways are coordinated to generate pathologically activated cancer associated fibroblasts (CAFs). Here, Ferrari et al show that stromal expression of Dickkopf-3 (DKK3) associates with aggressive tumours. DKK3 is a HSF-1 effector that activates β-catenin and YAP/TAZ, and DKK3-driven YAP/TAZ activation regulates the pro-tumorigenic behaviour of CAFs.

    • Nicola Ferrari
    • Romana Ranftl
    • Fernando Calvo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • It has been suggested that the cytoplasm of living cells can be described as a porous elastic meshwork bathed in an interstitial fluid. Microindentation tests now show that intracellular water redistribution plays a fundamental role in cellular rheology and that at physiologically relevant timescales cellular responses to mechanical stresses are consistent with such a poroelastic model.

    • Emad Moeendarbary
    • Léo Valon
    • Guillaume T. Charras
    Research
    Nature Materials
    Volume: 12, P: 253-261

  • Sahai and colleagues report that YAP is required for the establishment and function of cancer-associated fibroblasts. They propose that matrix stiffening promotes Src-mediated activation of YAP in fibroblasts, which is necessary for the cancer-associated fibroblast phenotype and further promotes matrix stiffening in a positive feedback loop.

    • Fernando Calvo
    • Nil Ege
    • Erik Sahai
    Research
    Nature Cell Biology
    Volume: 15, P: 637-646

  • Mechanical forces play important roles in cell biology and traction force microscopy (TFM) experiments have enabled quantification of the cell-generated forces when placed on substrates of distinct stiffnesses. Here the authors evaluate the effect of the Poisson’s ratio- one of the main descriptors of the material’s mechanical behaviour together with the Elastic Modulus, in the context of TFM experiments.

    • Yousef Javanmardi
    • Huw Colin-York
    • Emad Moeendarbary
    ResearchOpen Access
    Communications Physics
    Volume: 4, P: 1-10