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Communications Biology (1)

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Advanced filters: Author: Emanuel Di Valentin Clear advanced filters

PI3Kδ activity controls plasticity and discriminates between EMT and stemness based on distinct TGFβ signaling

Overexpression of isoform δ of phosphoinositide 3-kinase (PI3Kδ) promotes stemness in hepatocellular carcinoma cell lines and mouse liver, whereas its inhibition promotes EMT, suggesting a key role for PI3Kδ in epithelial plasticity.

Jean Agnetti
Vanessa Bou Malham
Ama Gassama-Diagne
ResearchOpen Access25 Jul 2022
Communications Biology

Volume: 5, P: 1-15

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PI3Kδ activity controls plasticity and discriminates between EMT and stemness based on distinct TGFβ signaling

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