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Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome

Marc Janier
Mohammed Almadjub
Madhuri Warren
Amendments and Corrections15 Feb 2022
Nature Genetics

Volume: 54, P: 358-360
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Dilated cardiomyopathy is the second most common cause for heart failure. Here the authors combine CRISPR base editors with the muscle-targeting viral vector AAVMYO to repair patient mutations in the cardiac splice factor Rbm20 in two mouse models.

Markus Grosch
Laura Schraft
Lars M. Steinmetz
ResearchOpen Access22 Jun 2023
Nature Communications

Volume: 14, P: 1-15
αTAT1 is the major α-tubulin acetyltransferase in mice

Acetylation of tubulin is proposed to be an important mechanism for the regulation of microtubule stability and diversity. Kalebic et al. generate mice lacking α-tubulin acetyltransferase activity, and reveal that an apparent absence of detectable tubulin acetylation is associated with impaired sperm motility.

Nereo Kalebic
Simona Sorrentino
Paul A. Heppenstall
Research10 Jun 2013
Nature Communications

Volume: 4, P: 1-10
Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB⁺ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB⁺ sensory neurons in the mouse skin attenuates this hypersensitivity.

Rahul Dhandapani
Cynthia Mary Arokiaraj
Paul A. Heppenstall
ResearchOpen Access24 Apr 2018
Nature Communications

Volume: 9, P: 1-14
Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice

A photosensitizer-tagged derivative of the interleukin-31 ligand that mediates the photoablation of itch-sensing skin neurons expressing the corresponding interleukin receptor reverses scratching behaviour of mice with atopic dermatitis.

Linda Nocchi
Nainika Roy
Paul A. Heppenstall
Research17 Dec 2018
Nature Biomedical Engineering

Volume: 3, P: 114-125
MicroRNA degradation by a conserved target RNA regulates animal behavior

RNA-directed miRNA degradation triggered by a brain-specific genome-encoded transcript regulates explorative and anxiety-like behavior in zebrafish and affects balance and motor learning in mice.

Angelo Bitetti
Allison C. Mallory
Alena Shkumatava
Research26 Feb 2018
Nature Structural & Molecular Biology

Volume: 25, P: 244-251
Deletion of LBR N-terminal domains recapitulates Pelger-Huet anomaly phenotypes in mouse without disrupting X chromosome inactivation

Young et al. report a new mouse model for Pelger-Huet anomaly, a genetic disorder caused by mutations in the Lamin B receptor gene (Lbr) that leads to abnormal neutrophil differentiation and skeletal defects. Using CRISPR/Cas-9 editing of Lbr, which has also been associated with X chromosome inactivation (XCI), they generate a mouse model that recapitulates the major phenotypes of the disease without majorly affecting XCI.

Alexander Neil Young
Emerald Perlas
Andrea Cerase
ResearchOpen Access12 Apr 2021
Communications Biology

Volume: 4, P: 1-8

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Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

αTAT1 is the major α-tubulin acetyltransferase in mice

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice

MicroRNA degradation by a conserved target RNA regulates animal behavior

Deletion of LBR N-terminal domains recapitulates Pelger-Huet anomaly phenotypes in mouse without disrupting X chromosome inactivation

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