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Showing 1–2 of 2 results
Advanced filters: Author: Emiko Fire Clear advanced filters

  • MCL-1 has emerged as a major oncogenic and chemoresistance factor. A screen of stapled peptide helices identified the MCL-1 BH3 domain as selectively inhibiting MCL-1 among the related anti-apoptotic Bcl-2 family members, providing insights into the molecular determinants of binding specificity and a new approach for sensitizing cancer cells to apoptosis.

    • Michelle L Stewart
    • Emiko Fire
    • Loren D Walensky
    Research
    Nature Chemical Biology
    Volume: 6, P: 595-601

  • Sema 3A is involved in the guidance of axons during nervous system development and induces the reorganization of actin filaments in the growth cones through the downstream protein CRMP1. Here the authors study the details of the molecular interaction between CRMP1 and the actin-binding protein Filamin-A in C. elegans.

    • Fumio Nakamura
    • Kosuke Kumeta
    • Yoshio Goshima
    Research
    Nature Communications
    Volume: 5, P: 1-14