Nature Search

STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor

Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling.

Bao-cun Zhang
Alice Pedersen
Søren R. Paludan
Research19 Sept 2025
Nature Immunology

P: 1-15
Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity

Choroid plexus produces the cerebrospinal fluid (CSF) that serves as the brain dispersion route for nutrients and waste products. Here, the authors show that CSF secretion remains high in aging rats with intact choroid plexus morphology, gene expression, and high metabolic rate.

Sara D. Lolansen
Eszter O. Révész
Nanna MacAulay
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Zinc mediates control of nitrogen fixation via transcription factor filamentation

Zinc acts as a second messenger in root nodules and regulates nitrogen homeostasis by controlling the transition between the active state and the inactive filamentous state of the novel transcriptional regulator FIXATION UNDER NITRATE (FUN).

Jieshun Lin
Peter K. Bjørk
Dugald Reid
ResearchOpen Access26 Jun 2024
Nature

Volume: 631, P: 164-169
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring

The structure of a spontaneously activated immune protein is determined by cryo-electron microscopy. This reveals the passage of an entire domain through a transient opening. The authors investigate the mechanism by multiple biophysical approaches.

Trine Amalie Fogh Gadeberg
Martin Høgholm Jørgensen
Gregers Rom Andersen
Research23 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 884-895
Genetic architecture in Greenland is shaped by demography, structure and selection

We illustrate that including data from Greenlandic Inuit can greatly reduce inequity in genomic-based healthcare in Greenland and other indigenous Arctic populations.

Frederik Filip Stæger
Mette K. Andersen
Anders Albrechtsen
ResearchOpen Access12 Feb 2025
Nature

Volume: 639, P: 404-410
Genome-resolved long-read sequencing expands known microbial diversity across terrestrial habitats

Nanopore sequencing of Danish soils and sediments yields genomes from over 15,000 microbial species, expanding the phylogenetic diversity of prokaryotes by 8%.

Mantas Sereika
Aaron James Mussig
Mads Albertsen
ResearchOpen Access24 Jul 2025
Nature Microbiology

Volume: 10, P: 2018-2030
Regulation of translation by site-specific ribosomal RNA methylation

Dynamic changes in 2′-O-methylation of rRNA in human cells lead to ribosome heterogeneity and result in altered translation of select mRNAs, correlating with changes in cellular phenotypes.

Martin D. Jansson
Sophia J. Häfner
Anders H. Lund
Research10 Nov 2021
Nature Structural & Molecular Biology

Volume: 28, P: 889-899
Alligamycin A, an antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

From the rapamycin-producer Streptomyces iranensis, authors report on the discovery of the antifungal candidate alligamycin A, which exhibited strong activities against several drug-resistant Aspergillus and Talaromyces.

Zhijie Yang
Yijun Qiao
Ling Ding
ResearchOpen Access26 Oct 2024
Nature Communications

Volume: 15, P: 1-12
Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Establishing the relative transmissibility of emerging variants of SARS-CoV-2 is key for pandemic management. Here, the authors use full-population administrative data from Denmark linked to PCR test results and estimate that the Alpha variant was ~60% higher than other strains circulating in early 2021.

Frederik Plesner Lyngse
Kåre Mølbak
Carsten Thure Kirkeby
ResearchOpen Access13 Dec 2021
Nature Communications

Volume: 12, P: 1-8
Genetic insights into biological mechanisms governing human ovarian ageing

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Katherine S. Ruth
Felix R. Day
John R. B. Perry
Research04 Aug 2021
Nature

Volume: 596, P: 393-397
Optics miniaturization strategy for demanding Raman spectroscopy applications

Authors present a centimeter-scale miniaturized Raman spectrometer using cheap nonstabilized laser diodes, densely packed optics, and non-cooled small sensors while the performance is comparable with expensive bulky research-grade Raman systems.

Oleksii Ilchenko
Yurii Pilhun
Anja Boisen
ResearchOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-14
A zero-valent palladium cluster-organic framework

Ultrasmall metallic clusters receive great attention for atom-efficient catalysts. Here a metallic cluster–organic framework is synthesized and characterized; authors demonstrate its stability and catalytic proficiency, paving the way for molecular-scale metal nanoparticle interlocking.

Xiyue Liu
James N. McPherson
Kasper S. Pedersen
ResearchOpen Access08 Feb 2024
Nature Communications

Volume: 15, P: 1-10
Sequence variants with large effects on cardiac electrophysiology and disease

Aberrant morphology of the QRS complex in an electrocardiogram can be associated with cardiac morbidity and mortality. Here, the authors perform genome-wide association studies for ten measures of the QRS complex in 81,192 individuals and find 86 previously unreported loci that associate with at least one parameter.

Kristjan Norland
Gardar Sveinbjornsson
Kari Stefansson
ResearchOpen Access22 Oct 2019
Nature Communications

Volume: 10, P: 1-10
High-resolution epidemiological landscape from ~290,000 SARS-CoV-2 genomes from Denmark

A high proportion of confirmed SARS-CoV-2 cases in Denmark were sequenced during the pandemic and linked to demographic, spatial and temporal data. Here, the authors analyse 290,000 genomes sampled in 2021 to demonstrate the value of this high coverage, detailed data set.

Mark P. Khurana
Jacob Curran-Sebastian
Samir Bhatt
ResearchOpen Access20 Aug 2024
Nature Communications

Volume: 15, P: 1-16
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

An expanded GWAS of birth weight and subsequent analysis using structural equation modeling and Mendelian randomization decomposes maternal and fetal genetic contributions and causal links between birth weight, blood pressure and glycemic traits.

Nicole M. Warrington
Robin N. Beaumont
Rachel M. Freathy
Research01 May 2019
Nature Genetics

Volume: 51, P: 804-814
Evaluation of urine dipstick tests in experimental porcine urinary tract infection with uropathogenic Escherichia coli

Kristian Stærk
Louise Kruse Jensen
Thomas Emil Andersen
ResearchOpen Access31 Jul 2023
Scientific Reports

Volume: 13, P: 1-6
Streptomyces alleviate abiotic stress in plant by producing pteridic acids

Soil microbiota can increase crop resilience to abiotic stressors. Here the authors show that Streptomyces produce bioactive spiroketal polyketides to enhance plant growth under drought and salt stress.

Zhijie Yang
Yijun Qiao
Ling Ding
ResearchOpen Access15 Nov 2023
Nature Communications

Volume: 14, P: 1-14
Potential of micro-exercise to prevent long-term sickness absence in the general working population: prospective cohort study with register follow-up

Lars L. Andersen
Sebastian V. Skovlund
Emil Sundstrup
ResearchOpen Access10 Feb 2022
Scientific Reports

Volume: 12, P: 1-8
Plant traits and associated ecological data from global change experiments and climate gradients in Norway

Vigdis Vandvik
Aud H. Halbritter
Brian J. Enquist
ResearchOpen Access25 Aug 2025
Scientific Data

Volume: 12, P: 1-24
New micro-hole zone catheter reduces residual urine and mucosal microtrauma in a lower urinary tract model

Brit Schrøder
Fabio Tentor
Lene Feldskov Nielsen
ResearchOpen Access27 Jan 2024
Scientific Reports

Volume: 14, P: 1-11
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

Individuals from a Greenlandic Inuit population with homozygous loss-of-function variants in ADCY3 (adenylate cyclase 3) have increased risk for obesity and type 2 diabetes. Carriers of rare ADCY3 variants in trans-ancestry populations also show increased association with type 2 diabetes.

Niels Grarup
Ida Moltke
Torben Hansen
Research08 Jan 2018
Nature Genetics

Volume: 50, P: 172-174
Development of an ex-vivo porcine lower urinary tract model to evaluate the performance of urinary catheters

Fabio Tentor
Brit Grønholt Schrøder
Lene Feldskov Nielsen
ResearchOpen Access24 Oct 2022
Scientific Reports

Volume: 12, P: 1-17
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal

Ninna Karsbæk Senftleber
Mette K. Andersen
Anders Albrechtsen
ResearchOpen Access30 Oct 2023
European Journal of Human Genetics

Volume: 32, P: 215-223
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Jens V. Andersen
Niels H. Skotte
Helle S. Waagepetersen
ResearchOpen Access16 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-13
Clinical performance of AI-integrated risk assessment pooling reveals cost savings even at high prevalence of COVID-19

Farzin Kamari
Esben Eller
Eivind Antonsen Segtnan
ResearchOpen Access17 Apr 2024
Scientific Reports

Volume: 14, P: 1-15
Accurate and fast identification of minimally prepared bacteria phenotypes using Raman spectroscopy assisted by machine learning

Benjamin Lundquist Thomsen
Jesper B. Christensen
Mikael Lassen
ResearchOpen Access30 Sept 2022
Scientific Reports

Volume: 12, P: 1-12
Bacteria-host transcriptional response during endothelial invasion by Staphylococcus aureus

Rasmus Birkholm Grønnemose
Christian Garde
Thomas Emil Andersen
ResearchOpen Access16 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
Preadipocytes from obese humans with type 2 diabetes are epigenetically reprogrammed at genes controlling adipose tissue function

Emil Andersen
Lars Roed Ingerslev
Romain Barrès
Research20 Feb 2018
International Journal of Obesity

Volume: 43, P: 306-318
Estimating narrow-sense heritability using family data from admixed populations

Georgios Athanasiadis
Doug Speed
Anders Albrechtsen
Research09 Apr 2020
Heredity

Volume: 124, P: 751-762
Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads

Linn S. Mamsen
Emil H. Ernst
Claus Y. Andersen
ResearchOpen Access21 Nov 2017
Scientific Reports

Volume: 7, P: 1-16
Progression of disease within 24 months (POD24) in follicular lymphoma in the rituximab era: incidence, clinicopathological risk factors, and outcome in a population-based Danish cohort

Marie Hairing Enemark
Jonas Klejs Hemmingsen
Maja Ludvigsen
CorrespondenceOpen Access30 Sept 2024
Blood Cancer Journal

Volume: 14, P: 1-4
Author Correction: Development of an ex-vivo porcine lower urinary tract model to evaluate the performance of urinary catheters

Fabio Tentor
Brit Grønholt Schrøder
Lene Feldskov Nielsen
Amendments and CorrectionsOpen Access20 Apr 2023
Scientific Reports

Volume: 13, P: 1-5

Search

STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor

Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity

Zinc mediates control of nitrogen fixation via transcription factor filamentation

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring

Genetic architecture in Greenland is shaped by demography, structure and selection

Genome-resolved long-read sequencing expands known microbial diversity across terrestrial habitats

Regulation of translation by site-specific ribosomal RNA methylation

Alligamycin A, an antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Genetic insights into biological mechanisms governing human ovarian ageing

Optics miniaturization strategy for demanding Raman spectroscopy applications

A zero-valent palladium cluster-organic framework

Sequence variants with large effects on cardiac electrophysiology and disease

High-resolution epidemiological landscape from ~290,000 SARS-CoV-2 genomes from Denmark

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Evaluation of urine dipstick tests in experimental porcine urinary tract infection with uropathogenic Escherichia coli

Streptomyces alleviate abiotic stress in plant by producing pteridic acids

Potential of micro-exercise to prevent long-term sickness absence in the general working population: prospective cohort study with register follow-up

Plant traits and associated ecological data from global change experiments and climate gradients in Norway

New micro-hole zone catheter reduces residual urine and mucosal microtrauma in a lower urinary tract model

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

Development of an ex-vivo porcine lower urinary tract model to evaluate the performance of urinary catheters

GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Clinical performance of AI-integrated risk assessment pooling reveals cost savings even at high prevalence of COVID-19

Accurate and fast identification of minimally prepared bacteria phenotypes using Raman spectroscopy assisted by machine learning

Bacteria-host transcriptional response during endothelial invasion by Staphylococcus aureus

Preadipocytes from obese humans with type 2 diabetes are epigenetically reprogrammed at genes controlling adipose tissue function

Estimating narrow-sense heritability using family data from admixed populations

Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads

Progression of disease within 24 months (POD24) in follicular lymphoma in the rituximab era: incidence, clinicopathological risk factors, and outcome in a population-based Danish cohort

Author Correction: Development of an ex-vivo porcine lower urinary tract model to evaluate the performance of urinary catheters

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