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A transiting planet with a period of about 8.5 days and a radius 0.4 times that of Jupiter is reported within the debris disk around the star AU Microscopii.

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

Gold nanoparticles typically considered inert in oxic waters accumulate in freshwater wetland subaquatic plants and are completely biotransformed to oxidized Au species by the associated cyanogenic biofilm.

In this double-blind, randomised, crossover trial, a diet rich in fermentable foods was shown to improve the glucose-lowering efficacy of metformin due, at least in part, to changes in gut microbiota composition.

A machine learning model incorporating a wide range of administrative medical and demographic data from the US Army outperformed suicide risk screening questions in predicting suicide attempts over the 6 month period following soldiers’ annual medical examinations.

Integrating CO₂ capture and electrochemical conversion avoids the thermal release of CO₂ and thus could potentially lower the energy needed to make useful products from CO₂, but choosing optimal system components is still challenging. Here the authors use piperazine alongside a nickel catalyst for capture and achieve high energy efficiency and stable CO production.

Ian Blair and colleagues use genome-wide linkage analysis and whole exome sequencing to identify mutations in the CCNF gene in large cohorts of amyotrophic lateral sclerosis and frontotemporal dementia patients. In addition to validating the mutations in international cohorts, the authors also show that mutant CCNFgene product affects ubiquitination and protein degradation in cultured cells.

3D visualisation of nano-scale crystals using X-ray ptychography shows that the aggregation of nanolites can increase magma viscosity, increasing the potential of magma fragmentation and a highly explosive volcanic eruption

Identifying genes involved in MYC-driven lymphoma reveals therapeutic vulnerabilities. Here, the authors show by using CRISPR knockout screens in primary cells in vivo that the GATOR1 complex suppresses MYC-driven lymphomagenesis, and that GATOR1-deficient lymphomas are sensitive to mTOR inhibitors.

Gene regulation and metabolism co-ordinate self-renewal and differentiation of neural precursors (NPCs) in the developing brain. Here the authors show that methylglyoxal, a glycolytic intermediate metabolite, promotes GADPH-dependent translational repression of Notch1, thereby promoting NPC differentiation.

Controlled breaking of a chemical bond by mechanical forces can provide key insight into reaction mechanisms. Here the authors, using atomic force microscopy and computations, measure the forces involved in breaking a single dative bond between a CO molecule and a ferrous phthalocyanine complex.

This systematic review and meta-analysis of 53 randomized controlled trials finds that educational interventions can help students reduce cognitive biases, with a small but statistically significant overall effect.

In this study, Marshall et al. studied early immune responses in the lung and blood after an aerosol infection with BCG. Understanding which cells respond to this infection can help us understand how to design new tuberculosis vaccines.

Microbial fuels cells present a way of generating electricity using the natural metabolism of microorganisms. Here the authors carry out single-cell current measurements ofGeobacter sulfurreducensDL-1 to determine the upper limits of microbial fuel cell performance.

In a phase 1b trial in three patients with Fanconi anemia, an irradiation- and busulfan-free conditioning regimen containing an anti-CD117 antibody, combined with T cell- and B cell-depleted haploidentical hematopoietic stem cell transplantation, was safe and led to high levels of donor engraftment.

An approach for synthesizing a one-atom-thick layer of a radioactive iodine isotope on a gold substrate is reported, with a substantial increase in the emission of low-energy electrons. Such a system might have potential for targeted nanoparticle therapies.

A photoconductor is a material in which electrical conductivity changes when it is illuminated — invariably increasing in response to impinging light. However, here it is shown that nanoparticle-based materials can be engineered, through the careful choice of the molecules used to stabilize the nanoparticles, to exhibit negative photoconductance: conductivity in these materials decreases in the presence of light.

Integrated Ocean Discovery Program Expedition 402 drilled two in-situ long mantle sections in the Tyrrhenian Sea, revealing that retention of large quantities of melts at mantle levels delayed the birth of an ocean basin.

Human Herpesvirus 6B (HHV-6) can cause fever, diarrhea and roseola rash. Here the authors present a cryoEM approach to image crude, minimally purified virus samples and employ it to determine the atomic structures of HHV-6B capsid and capsid-associated tegument protein complexes.

Precious metals recovery from electronics wastes, termed urban mining, is significant for a circular economy. Here, the authors reported a solvent-free and ultrafast process based on flash Joule heating to recover precious metals and remove toxic heavy metals in electronic wastes.

Oceans are on the front line of new planned climate actions, but understanding of novel marine-climate intervention development and deployment remains low. Here a survey among intervention practitioners allows identification of science and governance gaps for marine-climate interventions.

Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.

BMP signaling is important for multiple process, including craniofacial development, but relatively little is known about how BMP ligands are secreted. Here they show that embryonic palate mesenchyme cells undergo transient changes in intracellular calcium and that depolarization of these cells induces BMP4 release, suggesting that ion channels are a node in BMP4 signaling.

De novo microbial biosynthesis of vindoline and catharanthine using a highly engineered yeast and in vitro chemical coupling to vinblastine is carried out, positioning yeast as a scalable platform to produce many monoterpene indole alkaloids.

Characterising the response to SARS-CoV-2 post vaccination is critical in the appraisement of the induced immune response, performance and protective potential. Here the authors present data from a phase 4 clinical trial in autoimmune rheumatic disease patients 6 months post second dose of Sinovac-CoronaVac inactivated vaccine that show a marked reduction in antibody particularly in males or those under treatment with immune targeting therapies but saw no rise in COVID-19 disease.

Heating due to optical losses in metal nanoparticles, which is usually an unwanted side effect, is harnessed to realize low-power opto-thermoelectric nanotweezers.

Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine ChAdOx1 nCoV-19 are identified as correlates of protection against symptomatic infection.

In a large multinational cohort study, maternal, gestational or pregestational diabetes was associated with only a small-to-moderate risk of ADHD in offspring, contrary to previous estimates that showed stronger effect sizes, attributing the differences in findings to confounding by shared genetic and familial factors.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Bond et al. show that inducible PolG mutation in muscle causes mtDNA damage and muscle wasting. This is driven by the integrated stress response (ISR) and reduction in folate intermediates, linking impaired folate metabolism with ISR/disease induction.

This study reports on excavations of hearths and stone artefacts from 20,000-year-old deposits at Dargan Shelter, which at an elevation of 1,073 m is believed to be the oldest occupied high-altitude site in Australia.

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

A functional interfacial material has been developed for soft integration of bioelectronic devices with biological tissues. This has been applied in battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy as well as wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays.

In a large prospective phase 4 trial, vaccination with CoronaVac, an inactivated SARS-CoV-2 vaccine, elicited significantly lower virus-specific IgG antibodies and neutralizing antibodies in patients with autoimmune rheumatic diseases than in age- and sex-matched healthy control trial participants.

There has been much interest recently in the transport mechanisms of metals from hydrothermal vents. Here the authors found that nanoparticulate pyrite is not removed from the plume and can account for over 50% of filtered iron one metre from the vent mouth.

Mutations at two key positions in the TERT promoter are frequent drivers of cancer, but the role of rare, atypical mutations in this region remains unclear. Here, the authors demonstrate that atypical TERT promoter mutations develop after canonical ones due to locally elevated UV-induced DNA damage.

Data on antibody response to SARS-CoV-2 in infants directly compared with their mothers is limited. Stoddard et al. find distinct antibody profiles in infants, including elevated levels of antibody binding to Spike, elevated ADCC, and convergent antibody binding escape profiles in the Spike fusion peptide.

This is an experimental tool involving transport measurements to carefully estimate electronic band structures. The Landau levels in a decoupled monolayer graphene are used as probes to measure the band gap and bandwidth in multiple graphene systems.