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Gene-expression profiling in rheumatic disease: tools and therapeutic potential

Genomic technologies are becoming increasingly accessible to clinical research laboratories. Gene-expression profiling is a powerful tool that can be used for the identification of biomarkers, with potential widespread clinical applications in rheumatic disease. These applications, together with an overview of the latest technologies for gene-expression profiling, are outlined in this Review.

Jason W. Bauer
Hatice Bilgic
Emily C. Baechler
Reviews01 May 2009
Nature Reviews Rheumatology

Volume: 5, P: 257-265
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

Robert R Graham
Sergey V Kozyrev
Marta E Alarcón-Riquelme
Research16 Apr 2006
Nature Genetics

Volume: 38, P: 550-555
On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions

Using the semiconductor synthesis technology of maskless photolithography on microprocessor-grade silicon wafers, Jordan Price and colleagues synthesized microarrays containing every possible overlapping peptide in a linear sequence covering the N terminus of human histone H2B, including post-translational modifications. They demonstrated use of the 'on silico' peptide microarrays for the high-resolution mapping (at the single amino acid level) of epitopes targeted by commercially available H2B-specific antibodies and also by autoantibodies in samples from individuals with systemic lupus erythematosus.

Jordan V Price
Stephanie Tangsombatvisit
Chih Long Liu
Research19 Aug 2012
Nature Medicine

Volume: 18, P: 1434-1440
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Robert Graham and colleagues report results of a large-scale replication study for systemic lupus erythematosus (SLE) in individuals of European ancestry. Their findings expand the number of confirmed SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.

Vesela Gateva
Johanna K Sandling
Robert R Graham
Research18 Oct 2009
Nature Genetics

Volume: 41, P: 1228-1233
Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus

Jung-Rok Lee
D. James Haddon
Shan X. Wang
ResearchOpen Access09 Jun 2016
Scientific Reports

Volume: 6, P: 1-10

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Gene-expression profiling in rheumatic disease: tools and therapeutic potential

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus

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Gene-expression profiling in rheumatic disease: tools and therapeutic potential

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus

Search

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