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Showing 1–4 of 4 results
Advanced filters: Author: Emily C. Beckwitt Clear advanced filters

  • Using single-molecule imaging and manipulation, the authors show linker histone H1 preferentially forms phase-separated droplets with single-stranded nucleic acids over double-stranded DNA and nucleosomes, suggesting a noncanonical nuclear function.

    • Rachel Leicher
    • Adewola Osunsade
    • Shixin Liu
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 463-471

  • Using single-molecule visualization and manipulation, Chang et al. show that the eukaryotic Smc5/6 complex preferentially binds to and stabilizes ssDNA-dsDNA junctions, which could serve as the molecular basis for its diverse roles in genome maintenance.

    • Jeremy T-H. Chang
    • Shibai Li
    • Shixin Liu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • A combination of biochemical, single-molecule, and in vivo assays reveals that the UV-DDB complex that removes UV-induced DNA lesions via the nucleotide excision repair pathway also promotes removal of oxidative lesions via base excision repair.

    • Sunbok Jang
    • Namrata Kumar
    • Bennett Van Houten
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 695-703

  • It is not fully understood how XPA interacts with a DNA lesion during nucleotide excision repair. Here, the authors use single molecule analysis to study XPA–DNA interactions, including the DNA bend angle, protein stoichiometry, and diffusive properties during damage search.

    • Emily C. Beckwitt
    • Sunbok Jang
    • Bennett Van Houten
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14