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Showing 1–6 of 6 results
Advanced filters: Author: Emily J. Robitschek Clear advanced filters

  • The role of the tumour microenvironment in the response to immune checkpoint inhibitors in metastatic melanoma remains poorly understood. Here, single cell profiling of metastatic melanoma samples identifies associations of the mature dendritic enriched in immunoregulatory molecules subtype with immunotherapy response.

    • Jiekun Yang
    • Cassia Wang
    • Manolis Kellis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Mucosal melanoma (MM) is a cancer with poor prognosis derived from mucosal melanocytes. Here, the authors implement a combination of genetic changes that occur in MM patients in a zebrafish model, revealing the potential MM cell of origin and showing that patient and zebrafish MMs share a gene signature that is more metastatic and immune-evasive.

    • Swathy Babu
    • Jiajia Chen
    • Megan L. Insco
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • A CRISPR–Cas9 screen of chromatin regulators in mouse tumour models treated with immune checkpoint blockade identifies SETDB1 as an epigenetic checkpoint protein that suppresses tumour-intrinsic immunogenicity.

    • Gabriel K. Griffin
    • Jingyi Wu
    • Bradley E. Bernstein
    Research
    Nature
    Volume: 595, P: 309-314

  • Genetic and protein expression analyses of serially collected tumor biopsies from a patient with melanoma treated with immune checkpoint inhibitors provide insights into tumor microenvironment changes that occur during treatment resistance.

    • David Liu
    • Jia-Ren Lin
    • Genevieve M. Boland
    Research
    Nature Medicine
    Volume: 27, P: 985-992